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Moreover, the taste receptor used in the present invention may comprise a mutation such as a deletion, substitution, or addition of multiple amino acids, and preferably one or several amino acids in polypeptides having amino acid sequences shown in the aforementioned SEQ ID NOS: 1 to 44 (only even numbers from SEQ ID NOS: 1 to 44), as long as it functions as a taste receptor.

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In double the recommended daily dose ursodeoxycholic acid reduces elevated liver enzyme levels in patients with primary sclerosing cholangitis, but its use was associated with an increased risk of serious adverse events (the development of cirrhosis, varices, death or liver transplantation) in patients who received ursodeoxycholic acid compared with those who received placebo).

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The name of the aforementioned receptors used in the present invention, and the list of sequence numbers indicating the nucleotide sequences thereof and the amino acid sequences thereof, are shown in Table 1 above.

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